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총 53개의 글

전체ProteomicsBioinformaticsBiomarker ResearchNetwork Biology바이오마커바이오인포매틱스네트워크 생물학Bioinformatics ToolsTranscriptomics취업/면접문제해결도구/소프트웨어취업/커리어프로테오믹스AI/MLCareerClinical ResearchComputational BiologySystems Biology유전체학AI/신약개발시스템 생물학
Proteomics2026년 5월 22일· 13 min read

From DIA-NN Output to Paper Draft: A Complete AI-Assisted Proteomics Workflow (2026)

An honest, end-to-end guide to using AI across the full DIA-NN proteomics pipeline — from report.tsv quantification and downstream statistics through figure interpretation, Discussion writing, and a manuscript draft. Includes real prompts, where AI fails (with caught examples), verification checklists, and 2026 journal disclosure requirements.

#DIA-NN#proteomics#AI-assisted research#MaxLFQ
Proteomics2026년 5월 19일· 12 min read

Reproducing Park et al. 2026: Three Iterations of a Cross-Species ECM Proteomics Pipeline

A working record of reproducing the Park et al. 2026 cross-species extracellular matrix proteomics workflow (Porcine esophagus EEM vs Mouse Matrigel) — including three simulation iteration failures (circular logic, pseudocount artifact, gene-symbol vs Ensembl BioMart ortholog mapping) and independent PRIDE PXD023694 validation. Practical lessons for MaxQuant + riBAQ + DEP analysis.

#proteomics#cross-species#ECM#Matrigel
Proteomics2026년 5월 19일· 20 min read

공동연구자 의뢰로 Park et al. 2026을 재현하다 — 종간 ECM 프로테오믹스 분석에서 3번 반복하며 잡은 것들

Porcine 식도 EEM과 Mouse Matrigel을 비교하는 cross-species 프로테오믹스 분석 — Park et al. 2026 방법론을 재현하던 중 v1 시뮬레이션의 순환 논리, v2의 pseudocount artifact, BioMart 1:1 ortholog 검증 단계까지의 실제 워크플로 기록. PRIDE PXD023694 실데이터로 독립 검증한 결과까지.

#프로테오믹스#cross-species#ECM#Matrigel
Biomarker Research2026년 3월 30일· 27 min read

Biomarker Discovery and Validation: A Comprehensive Guide to the Workflow and Methods (2026)

Complete biomarker discovery and validation workflow — biomarker discovery methods (proteomics, metabolomics, genomics), study design, statistical pitfalls, regulatory pathway (FDA/CE-IVD/MFDS), and validation steps that separate publishable findings from clinically useful tests. Includes REMARK/TRIPOD checklists and real failure case studies.

#biomarker discovery#biomarker validation#biomarker discovery workflow#biomarker discovery methods
Biomarker Research2026년 3월 30일· 20 min read

Proteomics-Based Biomarker Discovery in the AI Era: A Critical Review of What's Working and What Isn't

A frank look at where proteomics biomarker discovery stands in 2026 — the genuine advances from AI/ML integration, the persistent failure modes that have plagued the field for 20 years, and the real-world workflows that are starting to produce clinically translatable results.

#proteomics biomarker discovery#AI biomarker#machine learning proteomics#clinical biomarkers